I Timothy 2:5 “For there is one God, and one mediator between God and men, the man Christ Jesus”

(Note: The Old Testament references pagan civilizations praying to pagan gods, but nowhere in the Bible is there an instance of a Christian praying to anyone other than God, nor is there a reference to a Christian asking a deceased Christian to pray for something.)
 

Exodus 20:4 “Thou shalt not make unto thee any graven image, or any likeness of any thing that is in heaven above, or that is in the earth beneath, or that is in the water under the earth”

The Catholic Church through the ages and in its practices today puts the virgin Mary on such a pedestal of importance that Mary, Jesus Christ, and God often appear to be near equals. The Bible truth is that Mary was simply a sinner who needed a savior like you and I, and to make an idol of Mary, to pray to Mary, and to hold Mary in such high doctrinal esteem is blasphemous and unscriptural.

I Thessalonians 1:9 "For they themselves shew of us what manner of entering in we had unto you, and how ye turned to God from idols to serve the living and true God;"

Mary had other children besides Jesus--she was not a perpetual virgin.

Mark 6:3-4 "Is not this the carpenter, the son of Mary, the brother of James, and Joses, and of Juda, and Simon? and are not his sisters here with us? And they were offended at him. But Jesus, said unto them, A prophet is not without honour, but in his own country, and among his own kin, and in his own house."

The Bible in multiple passages states that Jesus had brothers and sisters. Catholics often state that the term "brother" when related to Jesus simply means a brother in the faith, however, the following passages do a good job of showing that Jesus had actual brothers. The verses below list Jesus' brethren and his disciples as two separate entities.

John 2:12 "After this he [Jesus] went down to Capernaum, he, and his mother, and his brethren, and his disciples: and they continued there not many days."

Acts 1:13-14 "And when they were come in, they went up into an upper room, where abode both Peter, and James, and John, and Andrew, Philip, and Thomas, Bartholomew, and Matthew, James the son of Alphaeus, and Simon Zelotes, and Judas the brother of James. These all continued with one accord in prayer and supplication, with the women, and Mary the mother of Jesus, and with his brethren."

And, in the verse below Jesus gives us another distinction between his actual siblings and his fellow believers.

Matt. 12:46-50 "While he yet talked to the people, behold, his mother and his brethren stood without, desiring to speak with him. Then one said unto him, Behold, thy mother and thy brethren stand without, desiring to speak with thee. But he answered and said unto him that told him, Who is my mother? and who are my brethren? And he stretched forth his hand toward his disciples, and said, Behold my mother and my brethren! For whosoever shall do the will of my Father which is in heaven, the same is my brother, and sister, and mother."